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Self-limiting stem-cell niche signaling through degradation of a stem-cell receptor

Stem-cell niche signaling is short-range in nature, such that only stem cells but not their differentiating progeny receive self-renewing signals. At the apical tip of the Drosophila testis, 8 to 10 germline stem cells (GSCs) surround the hub, a cluster of somatic cells that organize the stem-cell n...

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Publicado en:PLoS Biol
Autores principales: Ladyzhets, Sophia, Antel, Matthew, Simao, Taylor, Gasek, Nathan, Cowan, Ann E., Inaba, Mayu
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7769618/
https://ncbi.nlm.nih.gov/pubmed/33315855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001003
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