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Safety surveillance and the estimation of risk in select populations: Flexible methods to control for confounding while targeting marginal comparisons via standardization

We consider the critical problem of pharmacosurveillance for adverse events once a drug or medical product is incorporated into routine clinical care. When making inference on comparative safety using large-scale electronic health records, we often encounter an extremely rare binary adverse outcome...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Stat Med
Hauptverfasser: Shi, Xu, Wellman, Robert, Heagerty, Patrick J., Nelson, Jennifer C., Cook, Andrea J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768802/
https://ncbi.nlm.nih.gov/pubmed/31823406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8410
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