Direct lysosome-based autophagy of lipid droplets in hepatocytes

Hepatocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of autophagy. An organelle-selective form of this process (macrolipophagy) results in the engulfment of LDs within double-membrane delimited structures (autophagosomes) before lysosomal fusion. Wheth...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Schulze, Ryan J., Krueger, Eugene W., Weller, Shaun G., Johnson, Katherine M., Casey, Carol A., Schott, Micah B., McNiven, Mark A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7768785/
https://ncbi.nlm.nih.gov/pubmed/33288726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011442117
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