Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Free extracellular heme has been shown to activate several compartments of innate immunity, acting as a danger-associated molecular pattern (DAMP) in hemolytic diseases. Although localized endothelial barrier (EB) disruption is an important part of inflammation that allows circulating leukocytes to...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Santaterra, Vanessa Araujo Gomes, Fiusa, Maiara Marx Luz, Hounkpe, Bidossessi Wilfried, Chenou, Francine, Tonasse, Wouitchekpo Vincent, da Costa, Loredana Nilkenes Gomes, Garcia-Weber, Diego, Domingos, Igor de Farias, de Lima, Franciele, Borba-Junior, Ivanio Teixeira, Araújo, Aderson da Silva, Lucena-Araújo, Antonio Roberto, Bezerra, Marcos André Cavalcante, dos Santos, Magnun Nueldo Nunes, Costa, Fernando Ferreira, Millán, Jaime, De Paula, Erich Vinicius
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767881/
https://ncbi.nlm.nih.gov/pubmed/33381108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.535147
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