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A respiratory/Hirschsprung phenotype in a three‐generation family associated with a novel pathogenic PHOX2B splice donor mutation

BACKGROUND: Mutations in the PHOX2B gene cause congenital central hypoventilation syndrome (CCHS), a rare autonomic nervous system dysfunction disorder characterized by a decreased ventilatory response to hypercapnia. Affected subjects develop alveolar hypoventilation requiring ventilatory support p...

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Detalhes bibliográficos
Publicado no:Mol Genet Genomic Med
Main Authors: Pace, Nikolai Paul, Pace Bardon, Michael, Borg, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767558/
https://ncbi.nlm.nih.gov/pubmed/33047879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.1528
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