Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs). Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances. No curative treatment is available and the pathophysiology is not fully elucidated. Protease-a...

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Publicado no:Cells
Main Authors: Pierre, Ophélie, Fouchard, Maxime, Buscaglia, Paul, Le Goux, Nelig, Leschiera, Raphaël, Mignen, Olivier, Fluhr, Joachim W., Misery, Laurent, Le Garrec, Raphaële
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7767211/
https://ncbi.nlm.nih.gov/pubmed/33348659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9122704
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