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The Effect of Deuteration on the H(2) Receptor Histamine Binding Profile: A Computational Insight into Modified Hydrogen Bonding Interactions

We used a range of computational techniques to reveal an increased histamine affinity for its H(2) receptor upon deuteration, which was interpreted through altered hydrogen bonding interactions within the receptor and the aqueous environment preceding the binding. Molecular docking identified the ar...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Hok, Lucija, Mavri, Janez, Vianello, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766521/
https://ncbi.nlm.nih.gov/pubmed/33353215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25246017
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