Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats

Type 2 diabetes mellitus (T2DM) is associated with advanced glycation end product (AGE) enrichment and considered a risk factor for intervertebral disc (IVD) degeneration. We hypothesized that systemic AGE inhibition, achieved using pyridoxamine (PM), attenuates IVD degeneration in T2DM rats. To ind...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Glaeser, Juliane D., Ju, Derek, Tawackoli, Wafa, Yang, Jae H., Salehi, Khosrowdad, Stefanovic, Tina, Kanim, Linda E. A., Avalos, Pablo, Kaneda, Giselle, Stephan, Stephen, Metzger, Melodie F., Bae, Hyun W., Sheyn, Dmitriy
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7766438/
https://ncbi.nlm.nih.gov/pubmed/33352698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21249709
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