11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

BACKGROUND: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) determines prereceptor metabolism and activation of glucocorticoids within peripheral tissues. Its dysregulation has been implicated in a wide array of metabolic diseases, leading to the development of selective 11β-HSD1 inhib...

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Veröffentlicht in:J Clin Endocrinol Metab
Hauptverfasser: Hardy, Rowan S, Botfield, Hannah, Markey, Keira, Mitchell, James L, Alimajstorovic, Zerin, Westgate, Connar S J, Sagmeister, Michael, Fairclough, Rebecca J, Ottridge, Ryan S, Yiangou, Andreas, Storbeck, Karl-Heinz H, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, Stewart, Paul M, Tomlinson, Jeremy W, Mollan, Susan P, Lavery, Gareth G, Sinclair, Alexandra J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Clinical Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7765633/
https://ncbi.nlm.nih.gov/pubmed/33098644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/clinem/dgaa766
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