The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach

The capacity of α-mangostin (α-MG) and β-mangostin (β-MG) from mangosteen pericarp on P-glycoprotein (Pgp) in silico, in vitro, and ex vivo was investigated in this study. Screening with the ADMET Predictor™ program predicted the two compounds to be both a Pgp inhibitor and Pgp substrate. The compou...

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Udgivet i:Molecules
Main Authors: Dechwongya, Panudda, Limpisood, Songpol, Boonnak, Nawong, Mangmool, Supachoke, Takeda-Morishita, Mariko, Kulsirirat, Thitianan, Rukthong, Pattarawit, Sathirakul, Korbtham
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7764676/
https://ncbi.nlm.nih.gov/pubmed/33322620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25245877
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