Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism

BACKGROUND: Glioblastoma remains highly lethal due to its inevitable recurrence. Most of this recurrence is found locally, indicating that postsurgical tumor-initiating cells (TICs) accumulate at the tumor edge. These edge-TICs then generate local recurrence harboring new core lesions. Here, we inve...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Li, Chaoxi, Cho, Hee Jin, Yamashita, Daisuke, Abdelrashid, Moaaz, Chen, Qin, Bastola, Soniya, Chagoya, Gustavo, Elsayed, Galal A, Komarova, Svetlana, Ozaki, Saya, Ohtsuka, Yoshihiro, Kunieda, Takeharu, Kornblum, Harley I, Kondo, Toru, Nam, Do-Hyun, Nakano, Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7764499/
https://ncbi.nlm.nih.gov/pubmed/33392508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa163
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