Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis

SIMPLE SUMMARY: Chronic liver injury and inflammation leads to excessive deposition of extracellular matrix, known as liver fibrosis, and the distortion of the hepatic parenchyma. Liver fibrosis may progress to cirrhosis, a condition in which hepatic function is impaired and most cases of liver tumo...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Claveria-Cabello, Alex, Colyn, Leticia, Uriarte, Iker, Latasa, Maria Ujue, Arechederra, Maria, Herranz, Jose M., Alvarez, Laura, Urman, Jesus M., Martinez-Chantar, Maria L., Banales, Jesus M., Sangro, Bruno, Rombouts, Krista, Oyarzabal, Julen, Marin, Jose J. G., Berasain, Carmen, Avila, Matias A., Fernandez-Barrena, Maite G.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7763137/
https://ncbi.nlm.nih.gov/pubmed/33322158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123748
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