Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer–binding factor 1

Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is required for normal kidney development and renal epithelial differentiation. Mutations of HNF-1β produce congenital kidney abnormalities and inherited renal tubulopathies. Here, we show that ablation of HNF-1β in...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Chan, Siu Chiu, Hajarnis, Sachin S., Vrba, Sophia M., Patel, Vishal, Igarashi, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762946/
https://ncbi.nlm.nih.gov/pubmed/33453998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015592
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