Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson’s disease

The LRRK2 gene has rare (p.G2019S) and common risk variants for Parkinson’s disease (PD). DNM3 has previously been reported as a genetic modifier of the age at onset in PD patients carrying the LRRK2 p.G2019S mutation. We analyzed this effect in a new cohort of LRRK2 p.G2019S heterozygotes (n = 724)...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Aging
Prif Awduron: Brown, Emmeline E., Blauwendraat, Cornelis, Trinh, Joanne, Rizig, Mie, Nalls, Mike A., Leveille, Etienne, Ruskey, Jennifer A., Jonvik, Hallgeir, Tan, Manuela M.X., Bandres-Ciga, Sara, Hassin-Baer, Sharon, Brockmann, Kathrin, Infante, Jon, Tolosa, Eduardo, Ezquerra, Mario, Ben Romdhan, Sawssan, Benmahdjoub, Mustapha, Arezki, Mohamed, Mhiri, Chokri, Hardy, John, Singleton, Andrew B., Alcalay, Roy N., Gasser, Thomas, Grosset, Donald G., Williams, Nigel M., Pittman, Alan, Gan-Or, Ziv, Fernandez-Santiago, Ruben, Brice, Alexis, Lesage, Suzanne, Farrer, Matthew, Wood, Nicholas, Morris, Huw R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2021
Pynciau:
Genetic Reports Abstract
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7762821/
https://ncbi.nlm.nih.gov/pubmed/32873436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.07.002
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