Pharmacogenetic Study of Trabectedin-Induced Severe Hepatotoxicity in Patients with Advanced Soft Tissue Sarcoma

SIMPLE SUMMARY: Trabectedin is a cytotoxic drug used for the treatment of advanced soft tissue sarcoma. One of the most frequent side effects is hepatotoxicity, which occurs in nearly 40% of patients. In this pharmacogenetic study, we aimed to identify genetic polymorphisms that could impair the fun...

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Udgivet i:Cancers (Basel)
Main Authors: Maillard, Maud, Chevreau, Christine, Le Louedec, Félicien, Cassou, Manon, Delmas, Caroline, Gourdain, Laure, Blay, Jean-Yves, Cupissol, Didier, Bompas, Emmanuelle, Italiano, Antoine, Isambert, Nicolas, Delcambre-Lair, Corinne, Penel, Nicolas, Bertucci, François, Guillemet, Cécile, Plenecassagnes, Julien, Foulon, Stéphanie, Chatelut, Étienne, Le Cesne, Axel, Thomas, Fabienne
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761985/
https://ncbi.nlm.nih.gov/pubmed/33291741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12123647
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