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Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-ActivityAnalysis of Substituted 5,8-Dihydroxy-1,4-naphthoquinones and Their O- and S-Glycoside Derivatives Tested against Neuro-2a Cancer Cells

Based on 6,7-substituted 2,5,8-trihydroxy-1,4-naphtoquinones (1,4-NQs) derived from sea urchins, five new acetyl-O-glucosides of NQs were prepared. A new method of conjugation of per-O-acetylated 1-mercaptosaccharides with 2-hydroxy-1,4-NQs through a methylene spacer was developed. Methylation of 2-...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mar Drugs
Main Authors: Polonik, Sergey, Likhatskaya, Galina, Sabutski, Yuri, Pelageev, Dmitry, Denisenko, Vladimir, Pislyagin, Evgeny, Chingizova, Ekaterina, Menchinskaya, Ekaterina, Aminin, Dmitry
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761386/
https://ncbi.nlm.nih.gov/pubmed/33260299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md18120602
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