Proteomic and Transcriptomic Analysis Identify Spliceosome as a Significant Component of the Molecular Machinery in the Pituitary Tumors Derived from POU1F1- and NR5A1-Cell Lineages

Background: Pituitary adenomas (PA) are the second most common tumor in the central nervous system and have low counts of mutated genes. Splicing occurs in 95% of the coding RNA. There is scarce information about the spliceosome and mRNA-isoforms in PA, and therefore we carried out proteomic and tra...

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Pubblicato in:Genes (Basel)
Autori principali: Taniguchi-Ponciano, Keiko, Peña-Martínez, Eduardo, Silva-Román, Gloria, Vela-Patiño, Sandra, Guzman-Ortiz, Ana Laura, Quezada, Hector, Gomez-Apo, Erick, Chavez-Macias, Laura, Mercado-Medrez, Sophia, Vargas-Ortega, Guadalupe, Espinosa-de-los-Monteros, Ana Laura, Gonzales-Virla, Baldomero, Ferreira-Hermosillo, Aldo, Espinosa-Cardenas, Etual, Ramirez-Renteria, Claudia, Sosa, Ernesto, Lopez-Felix, Blas, Guinto, Gerardo, Marrero-Rodríguez, Daniel, Mercado, Moises
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7760979/
https://ncbi.nlm.nih.gov/pubmed/33261069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11121422
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