Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity

[Image: see text] Diclofenac (DCF) is widely used as a nonsteroidal anti-inflammatory drug; however, it is associated with severe liver injury. This adverse reaction is thought to be related to the reactive quinone imine (QI) and acyl glucuronide (AG) metabolites of DCF, but it remains controversial...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Tateishi, Yasuhiro, Ohe, Tomoyuki, Ogawa, Mai, Takahashi, Kyoko, Nakamura, Shigeo, Mashino, Tadahiko
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758955/
https://ncbi.nlm.nih.gov/pubmed/33376898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c04942
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