ISG15 protects human Tregs from interferon alpha‐induced contraction in a cell‐intrinsic fashion

OBJECTIVES: Type I interferons (IFNs) inhibit regulatory T‐cell (Treg) expansion and activation, making them beneficial in antiviral responses, but detrimental in autoimmune diseases. Herein, we investigate the role of ISG15 in human Tregs in the context of refractoriness to type I IFN stimulation....

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Pacella, Ilenia, Spinelli, Francesca Romana, Severa, Martina, Timperi, Eleonora, Tucci, Gloria, Zagaglioni, Marta, Ceccarelli, Fulvia, Rizzo, Fabiana, Coccia, Eliana M, Patel, Roosheel S, Martin‐Fernandez, Marta, Bogunovic, Dusan, Conti, Fabrizio, Barnaba, Vincenzo, Piconese, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758615/
https://ncbi.nlm.nih.gov/pubmed/33376595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1221
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