b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region

Proteoglycans are structurally and functionally diverse biomacromolecules found abundantly on cell membranes and in the extracellular matrix. They consist of a core protein linked to glycosaminoglycan chains via a tetrasaccharide linkage region. Here, we show that CRISPR/Cas9-mediated b3galt6 knock-...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Delbaere, Sarah, De Clercq, Adelbert, Mizumoto, Shuji, Noborn, Fredrik, Bek, Jan Willem, Alluyn, Lien, Gistelinck, Charlotte, Syx, Delfien, Salmon, Phil L., Coucke, Paul J., Larson, Göran, Yamada, Shuhei, Willaert, Andy, Malfait, Fransiska
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758351/
https://ncbi.nlm.nih.gov/pubmed/33363150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.597857
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