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FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration

BACKGROUND: Intervertebral disk (IVD) degeneration is the most common cause of lower back pain. Inhibiting inflammation is a key strategy for delaying IVD degeneration. Tacrolimus (FK506) is a potent immunosuppressive agent that is also beneficial to chondrocytes via alleviating inflammation. Howeve...

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Bibliografiske detaljer
Udgivet i:Front Cell Dev Biol
Main Authors: Ge, Jun, Wang, Yingjie, Yan, Qi, Wu, Cenhao, Yu, Hao, Yang, Huilin, Zou, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758291/
https://ncbi.nlm.nih.gov/pubmed/33363168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.608308
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