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An optimal control approach for enhancing natural killer cells' secretion of cytolytic molecules

Natural killer (NK) cells are immune effector cells that can detect and lyse cancer cells. However, NK cell exhaustion, a phenotype characterized by reduced secretion of cytolytic models upon serial stimulation, limits the NK cell's ability to lyse cells. In this work, we investigated in silico...

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Detalhes bibliográficos
Publicado no:APL Bioeng
Main Authors: Makaryan, Sahak Z., Finley, Stacey D.
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758091/
https://ncbi.nlm.nih.gov/pubmed/33376936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/5.0024726
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