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Demographic history mediates the effect of stratification on polygenic scores
Population stratification continues to bias the results of genome-wide association studies (GWAS). When these results are used to construct polygenic scores, even subtle biases can cumulatively lead to large errors. To study the effect of residual stratification, we simulated GWAS under realistic mo...
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| Publicado no: | eLife |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7758063/ https://ncbi.nlm.nih.gov/pubmed/33200985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61548 |
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