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Distinct polymorphisms in a single herpesvirus gene are capable of enhancing virulence and mediating vaccinal resistance

Modified-live herpesvirus vaccines are widely used in humans and animals, but field strains can emerge that have a higher virulence and break vaccinal protection. Since the introduction of the first vaccine in the 1970s, Marek’s disease virus overcame the vaccine barrier by the acquisition of numero...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Conradie, Andelé M., Bertzbach, Luca D., Trimpert, Jakob, Patria, Joseph N., Murata, Shiro, Parcells, Mark S., Kaufer, Benedikt B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7758048/
https://ncbi.nlm.nih.gov/pubmed/33306739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009104
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