Antitumor Activity and Mechanism Study of Riluzole and Its Derivatives

To explore novel antitumor agents with high efficiency and low toxicity, riluzole alkyl derivatives (4a-4i) were synthesized. Their anti-proliferative activities against HeLa, HepG2, SP2/0, and MCF-7 cancer cell lines were assessed by the CCK-8 assay and compared with human normal liver (LO2) cells....

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Detalhes bibliográficos
Publicado no:Iran J Pharm Res
Main Authors: Wu, Xiang-Long, Liu, Liu, Wang, Qing-Chuan, Wang, Hai-Fang, Zhao, Xiang-Rong, Lin, Xu-Bin, Lv, Wen-Jun, Niu, Yin-Bo, Lu, Ting-Li, Mei, Qi-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Shaheed Beheshti University of Medical Sciences 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757987/
https://ncbi.nlm.nih.gov/pubmed/33680024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22037/ijpr.2020.1101149
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