A cost/benefit analysis of clinical trial designs for COVID-19 vaccine candidates

We compare and contrast the expected duration and number of infections and deaths averted among several designs for clinical trials of COVID-19 vaccine candidates, including traditional and adaptive randomized clinical trials and human challenge trials. Using epidemiological models calibrated to the...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Berry, Donald A., Berry, Scott, Hale, Peter, Isakov, Leah, Lo, Andrew W., Siah, Kien Wei, Wong, Chi Heem
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7757868/
https://ncbi.nlm.nih.gov/pubmed/33362278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0244418
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