Liposomal FRET Assay Identifies Potent Drug‐Like Inhibitors of the Ceramide Transport Protein (CERT)

Ceramide transfer protein (CERT) mediates non‐vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate‐limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedious binding assays or non‐homogenous transfer assays using ra...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Samaha, Doaa, Hamdo, Housam H., Cong, Xiaojing, Schumacher, Fabian, Banhart, Sebastian, Aglar, Öznur, Möller, Heiko M., Heuer, Dagmar, Kleuser, Burkhard, Saied, Essa M., Arenz, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756341/
https://ncbi.nlm.nih.gov/pubmed/33047409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202003283
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