In Vivo and In Vitro Potency of Polyphosphazene Immunoadjuvants with Hepatitis C Virus Antigen and the Role of Their Supramolecular Assembly

Two well-defined synthetic polyphosphazene immunoadjuvants, PCPP and PCEP, were studied for their ability to potentiate immune response to Hepatitis C virus (HCV) E2 glycoprotein antigen in vivo. We report that PCEP induced significantly higher serum neutralization and HCV specific IgG titers in mic...

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Veröffentlicht in:Mol Pharm
Hauptverfasser: Andrianov, Alexander K., Marini, Alexander, Wang, Ruixue, Chowdhury, Ananda, Agnihotri, Pragati, Yunus, Abdul S., Pierce, Brian G., Mariuzza, Roy A., Fuerst, Thomas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755742/
https://ncbi.nlm.nih.gov/pubmed/32530637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00487
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