Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the neutralizing antibody-mediated immune response. Through study of a neutralizing monoclonal antibody termed mAb P-4G2, which neutralizes the zoonotic...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Rissanen, Ilona, Stass, Robert, Krumm, Stefanie A, Seow, Jeffrey, Hulswit, Ruben JG, Paesen, Guido C, Hepojoki, Jussi, Vapalahti, Olli, Lundkvist, Åke, Reynard, Olivier, Volchkov, Viktor, Doores, Katie J, Huiskonen, Juha T, Bowden, Thomas A
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Microbiology and Infectious Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755396/
https://ncbi.nlm.nih.gov/pubmed/33349334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58242
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