Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjugation methods for improving ADC homogeneity. Most sit...

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Publicado no:Mol Pharm
Main Authors: Behrens, Christopher R., Ha, Edward H., Chinn, Lawrence L., Bowers, Simeon, Probst, Gary, Fitch-Bruhns, Maureen, Monteon, Jorge, Valdiosera, Amanda, Bermudez, Abel, Liao-Chan, Sindy, Wong, Tiffany, Melnick, Jonathan, Theunissen, Jan-Willem, Flory, Mark R., Houser, Derrick, Venstrom, Kristy, Levashova, Zoia, Sauer, Paul, Migone, Thi-Sau, van der Horst, Edward H., Halcomb, Randall L., Jackson, David Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755308/
https://ncbi.nlm.nih.gov/pubmed/26393951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00432
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