A Triazinone Derivative Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity

A novel HIV-1 inhibitor, 6-(tert-butyl)-4-phenyl-4-(trifluoromethyl)-1H,3H-1,3,5-triazin-2-one (compound 1), was identified from a compound library screened for the ability to inhibit HIV-1 replication. EC(50) values of compound 1 were found to range from 107.9 to 145.4 nm against primary HIV-1 clin...

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Bibliografski detalji
Izdano u:ChemMedChem
Glavni autori: Urano, Emiko, Miyauchi, Kosuke, Kojima, Yoko, Hamatake, Makiko, Ablan, Sherimay D., Fudo, Satoshi, Freed, Eric O., Hoshino, Tyuji, Komano, Jun
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754980/
https://ncbi.nlm.nih.gov/pubmed/27634404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600375
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