Crystal structure of Legionella pneumophila dephospho-CoA kinase reveals a non-canonical conformation of P-loop

Dephospho-CoA kinase (DPCK; EC 2.7.1.24) catalyzes the final step in the coenzyme A biosynthetic pathway. DPCK transfers a phosphate group from ATP to the 3-hydroxyl group of the ribose of dephosphocoenzyme A (dCoA) to yield CoA and ADP. Upon the binding of ligands, large conformational changes is i...

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Detalhes bibliográficos
Publicado no:J Struct Biol
Main Authors: Gong, Xiaojian, Chen, Xiaofang, Yu, Dongmin, Zhang, Nannan, Zhu, Zhongliang, Niu, Liwen, Mao, Yuxin, Ge, Honghua
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754714/
https://ncbi.nlm.nih.gov/pubmed/25449315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2014.10.008
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