Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons

BACKGROUND: The chromosome 22q11.2 deletion is an extremely high risk genetic factor for various neuropsychiatric disorders; however, the 22q11.2 deletion-related brain pathology in humans at the cellular and molecular levels remains unclear. METHODS: We generated iPS cells from healthy controls (co...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Arioka, Yuko, Shishido, Emiko, Kushima, Itaru, Suzuki, Toshiaki, Saito, Ryo, Aiba, Atsu, Mori, Daisuke, Ozaki, Norio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753137/
https://ncbi.nlm.nih.gov/pubmed/33341442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103138
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