Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1

Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallographic data makes noncoding RNA regions challenging targets to study in the f...

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Publicat a:Comput Struct Biotechnol J
Autors principals: Ondono, Raul, Lirio, Ángel, Elvira, Carlos, Álvarez-Marimon, Elena, Provenzano, Claudia, Cardinali, Beatrice, Pérez-Alonso, Manuel, Perálvarez-Marín, Alex, Borrell, José I., Falcone, Germana, Estrada-Tejedor, Roger
Format: Artigo
Idioma:Inglês
Publicat: Research Network of Computational and Structural Biotechnology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753043/
https://ncbi.nlm.nih.gov/pubmed/33363709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.053
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