Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury

Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase domain-like protein). Necroptosis has emerged as important cell death involved in the pathogenesis of various...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Dev Biol
Päätekijät: Xia, Kaijiang, Zhu, Fang, Yang, Chengkui, Wu, Shuwei, Lin, Yu, Ma, Haikuo, Yu, Xiaoliang, Zhao, Cong, Ji, Yuting, Ge, Wenxiang, Wang, Jingrui, Du, Yayun, Zhang, Wei, Yang, Tao, Zhang, Xiaohu, He, Sudan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2020
Aiheet:
Cell and Developmental Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753040/
https://ncbi.nlm.nih.gov/pubmed/33364238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.606119
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