TCR-mimic antibody-drug conjugates targeting intracellular tumor-specific mutant antigen KRAS G12V mutation

Limited clinical application of antibody-drug conjugates (ADCs) targeting tumor associated antigens (TAAs) is usually caused by on-target off-tumor side effect. Tumor-specific mutant antigens (TSMAs) only expressed in tumor cells which are ideal targets for ADCs. In addition, intracellular somatic m...

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Vydáno v:Asian J Pharm Sci
Hlavní autoři: Shen, Ying, Wei, Xiaoyue, Jin, Shijie, Wu, Yue, Zhao, Wenbin, Xu, Yingchun, Pan, Liqiang, Zhou, Zhan, Chen, Shuqing
Médium: Artigo
Jazyk:Inglês
Vydáno: Shenyang Pharmaceutical University 2020
Témata:
Original Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7750800/
https://ncbi.nlm.nih.gov/pubmed/33363632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajps.2020.01.002
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