CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish

The transcription factor Nrf2a induces a cellular antioxidant response and provides protection against chemical-induced oxidative stress, as well as playing a critical role in development and disease. Zebrafish are a powerful model to study the role of Nrf2a in these processes but have been limited...

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Vydáno v:Chem Res Toxicol
Hlavní autoři: Mills, Margaret G., Ramsden, Richard, Ma, Eva Y., Corrales, Jone, Kristofco, Lauren A., Steele, W. Baylor, Saari, Gavin N., Melnikov, Fjodor, Kostal, Jakub, Kavanagh, Terrance J., Zimmerman, Julie B., Voutchkova-Kostal, Adelina M., Brooks, Bryan W., Coish, Philip, Anastas, Paul T., Gallagher, Evan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749997/
https://ncbi.nlm.nih.gov/pubmed/31858786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00346
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