Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis

BACKGROUND & AIMS: In autoimmune hepatitis (AIH) imbalance between Treg and Th17-cells has been linked to low levels of CD39, an ectoenzyme that hydrolyses ATP ultimately generating immunosuppressive adenosine. Upregulation of CD39 results from activation of aryl-hydrocarbon-receptor (AHR), whic...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Vuerich, Marta, Harshe, Rasika, Frank, Luiza Abrahão, Mukherjee, Samiran, Gromova, Barbora, Csizmadia, Eva, Nasser, Imad AM, Ma, Yun, Bonder, Alan, Patwardhan, Vilas, Robson, Simon C., Longhi, Maria Serena
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749856/
https://ncbi.nlm.nih.gov/pubmed/32663496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.06.044
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