Mutant myogenin promoter-controlled oncolytic adenovirus selectively kills PAX3-FOXO1-positive rhabdomyosarcoma cells

The PAX3-FOXO1 fusion gene functions as a transactivator and increases expression of many cancer-related genes. These lead to metastases and other unfavorable outcomes for alveolar rhabdomyosarcoma (ARMS) patients. In order to target ARMS with the PAX3-FOXO1 transactivator, we developed an Oncolytic...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Yoshida, Hideki, Sato-Dahlman, Mizuho, Hajeri, Praveensingh, Jacobsen, Kari, Koodie, Lisa, Yanagiba, Chikako, Shanley, Ryan, Yamamoto, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749408/
https://ncbi.nlm.nih.gov/pubmed/33338875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100997
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