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Nonequilibrium models of optimal enhancer function

In prokaryotes, thermodynamic models of gene regulation provide a highly quantitative mapping from promoter sequences to gene-expression levels that is compatible with in vivo and in vitro biophysical measurements. Such concordance has not been achieved for models of enhancer function in eukaryotes....

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Publicado en:Proc Natl Acad Sci U S A
Main Authors: Grah, Rok, Zoller, Benjamin, Tkačik, Gašper
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749321/
https://ncbi.nlm.nih.gov/pubmed/33268497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006731117
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