siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model

Systemic or localized application of glucocorticoids (GCs) can lead to iatrogenic ocular hypertension, which is a leading cause of secondary open-angle glaucoma and visual impairment. Previous work has shown that dexamethasone increases zonula occludens-1 (ZO-1) protein expression in trabecular mesh...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Cassidy, Paul S., Kelly, Ruth A., Reina-Torres, Ester, Sherwood, Joseph M., Humphries, Marian M., Kiang, Anna-Sophia, Farrar, G. Jane, O’Brien, Colm, Campbell, Matthew, Stamer, W. Daniel, Overby, Darryl R., Humphries, Pete, O’Callaghan, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749298/
https://ncbi.nlm.nih.gov/pubmed/33376757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.022
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