Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms

MNRR1 (CHCHD2) is a bi-organellar regulator of mitochondrial function that directly activates cytochrome c oxidase in the mitochondria and functions in the nucleus as a transcriptional activator for hundreds of genes. Since MNRR1 depletion contains features of a mitochondrial disease phenotype, we e...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Aras, Siddhesh, Purandare, Neeraja, Gladyck, Stephanie, Somayajulu-Nitu, Mallika, Zhang, Kezhong, Wallace, Douglas C., Grossman, Lawrence I.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7749287/
https://ncbi.nlm.nih.gov/pubmed/33257573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005877117
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