Study protocol for SPARED trial: randomised non-inferiority phase III trial comparing dexamethasone on day 1 with dexamethasone on days 1–4, combined with neurokinin-1 receptor antagonist, palonosetron and olanzapine (5 mg) in patients receiving cisplatin-based chemotherapy

INTRODUCTION: Dexamethasone (DEX) is administered for multiple days to prevent chemotherapy-induced nausea and vomiting for patients receiving highly emetogenic chemotherapy (HEC); however, its notorious side effects have been widely reported. Although our multicentre randomised double-blind compara...

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Vydáno v:BMJ Open
Hlavní autoři: Minatogawa, Hiroko, Izawa, Naoki, Kawaguchi, Takashi, Miyaji, Tempei, Shimomura, Kazuhiro, Kazunori, Honda, Iihara, Hirotoshi, Ohno, Yasushi, Inada, Yusuke, Arioka, Hitoshi, Morita, Hajime, Hida, Naoya, Sugawara, Mitsuhiro, Katada, Chikatoshi, Nawata, Shuichi, Ishida, Hiroo, Tsuboya, Ayako, Tsuda, Takashi, Yamaguchi, Takuhiro, Nakajima, Takako Eguchi
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747608/
https://ncbi.nlm.nih.gov/pubmed/33334838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2020-041737
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