Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

A role for cancer cell epithelial-to-mesenchymal transition (EMT) in cancer is well established. Here, we show that, in addition to cancer cell EMT, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition (MET) in host mesenchymal stem cells (MSCs). These reprogra...

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Pubblicato in:Cell Rep
Autori principali: Fan, Huihui, Atiya, Huda I., Wang, Yeh, Pisanic, Thomas R., Wang, Tza-Huei, Shih, Ie-Ming, Foy, Kelly K., Frisbie, Leonard, Buckanovich, Ronald J., Chomiak, Alison A., Tiedemann, Rochelle L., Rothbart, Scott B., Chandler, Chelsea, Shen, Hui, Coffman, Lan G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747301/
https://ncbi.nlm.nih.gov/pubmed/33296650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108473
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