Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to provide important preclinical data on the effects...

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Bibliografske podrobnosti
izdano v:Front Mol Neurosci
Main Authors: Szczygieł, Julia Alicja, Danielsen, Kira Iben, Melin, Esbjörn, Rosenkranz, Søren Hofman, Pankratova, Stanislava, Ericsson, Annika, Agerman, Karin, Kokaia, Merab, Woldbye, David Paul Drucker
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746806/
https://ncbi.nlm.nih.gov/pubmed/33343295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.603409
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