Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019 (COVID-19), a global healthcare and economic catastrophe. Understanding of the host immune response to SARS-CoV-2 is still in its infancy. A 382-nt deletion strain lacking ORF8 (Δ382 herein) was isolated in Singapore...

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Publicat a:PLoS Pathog
Autors principals: Gamage, Akshamal M., Tan, Kai Sen, Chan, Wharton O. Y., Liu, Jing, Tan, Chee Wah, Ong, Yew Kwang, Thong, Mark, Andiappan, Anand K., Anderson, Danielle E., Wang, De Yun, Wang, Lin-Fa
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746279/
https://ncbi.nlm.nih.gov/pubmed/33284849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009130
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