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Infection-induced 5′-half molecules of tRNA(HisGUG) activate Toll-like receptor 7
Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored. Here, we report 5′-tRNA half molecules as abundant activators of TLR7. Mycobacterial infection and accompa...
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| 發表在: | PLoS Biol |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7745994/ https://ncbi.nlm.nih.gov/pubmed/33332353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000982 |
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