Refined Prediction of Pharmacokinetic Kratom-Drug Interactions: Time-Dependent Inhibition Considerations

Preparations from the leaves of the kratom plant (Mitragyna speciosa) are consumed for their opioid-like effects. Several deaths have been associated with kratom used concomitantly with some drugs. Pharmacokinetic interactions are potential underlying mechanisms of these fatalities. Accumulating in...

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Publicat a:J Pharmacol Exp Ther
Autors principals: Tanna, Rakshit S., Tian, Dan-Dan, Cech, Nadja B., Oberlies, Nicholas H., Rettie, Allan E., Thummel, Kenneth E., Paine, Mary F.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2021
Matèries:
Metabolism, Transport, and Pharmacogenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745086/
https://ncbi.nlm.nih.gov/pubmed/33093187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000270
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