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Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel

SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel HCN2 in the family of so-called pacemaker chann...

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Pubblicato in:Nat Commun
Autori principali: Schmidpeter, Philipp A. M., Rheinberger, Jan, Nimigean, Crina M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744796/
https://ncbi.nlm.nih.gov/pubmed/33328472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20104-4
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