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Validation and assessment of preanalytical factors of a fluorometric in vitro assay for glucocerebrosidase activity in human cerebrospinal fluid

Lysosomal dysfunction is an emerging feature in the pathology of Parkinson’s disease and Dementia with Lewy bodies. Mutations in the GBA gene, encoding the enzyme Glucocerebrosidase (GCase), have been identified as a genetic risk factor for these synucleinopathies. As a result, there has been a grow...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Oftedal, Linn, Maple-Grødem, Jodi, Førland, Marthe Gurine Gunnarsdatter, Alves, Guido, Lange, Johannes
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744549/
https://ncbi.nlm.nih.gov/pubmed/33328543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79104-5
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